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KMID : 0378019840270110114
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New Medical Journal
1984 Volume.27 No. 11 p.114 ~ p.118
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The Clinical Trial of Liver Extract (Adelavin^(®)) in Chronic Active Hepatitis
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Abstract
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The purified protein-free liver extracts have been used for past many years in the treatment of both acute and chronic liver diseases.
To evaluate the therapeutic effect of liver extract, Adelavin®, this clinical study was carried out in 25 HBsAg posittve patients with histologically proven chronic active hepatitis.
Four ml of Adelavin® mixed with 5% dextrose in water 500m1 was infused intravenously daily for 4 weeks.
The following results were obtained.
1. The subjective symptoms were improved after 4 weeks-administration by improvement rate 70% in fatigue, 60% in anorexia, 75% in nausea, 45% in indigestion, 67% in abdominal discomfort.
2. There were significant improvements in SGOT, SGPT, alkaline phosphatase, total protein after 2 weeks-administration than pre-administration (P<0.001), in albumin after 4 weeks-administration (P<0.001), in prothrombin time after 3 weeks-administration (P<0.05).
3. In serum protein electrophoresis, there was significant increase of albumin after 4 weeks-administration (P<0. 001) and significant decrease of gamma globulin after 4 weeks administration (P<0. 001).
4. In radioimmunoassay of HBV marker, there was no change of HBV marker after 4 weeks-administration.
5. There were transient nausea in one patient, skin rash with fever in one patient, but no abnormality in complete blood count and urinanalysis during the administration.
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